Investigations on the effects of a topical ceramides-containing emulsion (Allerderm Spot on) on clinical signs and skin barrier function in dogs with atopic dermatitis: a double-blinded, randomized, controlled study

Skin barrier is impaired in canine atopic dermatitis (AD) and topical application of ceramides has been suggested to be beneficial. This study evaluated the effects of a ceramides-containing emulsion on clinical signs and skin barrier in a double-blinded, placebo-controlled trial. Dogs diagnosed with AD were enrolled and divided into two equal groups. Half received ceramide emulsion (Allerderm spot-on) 3x/week for 4 weeks, and the rest received control. Both investigators and owners were blinded to group allocation. Treated areas included pinna, antebrachial, axilla, and groin. Dogs were evaluated on day 0, 14, and 28 for clinical signs and skin barrier function. Clinical signs were scored using the Canine Atopic Dermatitis Extent and Severity Index (CADESI) score and skin barrier was assessed by measurement of Transepidermal Water Loss (TEWL). Owners scored pruritus and overall improvement. One investigator did all clinical evaluations.

Informations supplémentaires

  • Année: samedi, 02 novembre 2013
  • Référence: Intern J Appl Res Vet Med 2013 11(2): 110-116.
  • Auteur(s): Marsella, R., D. Genovese, et al.
  • Commentaire(s):

    On notera que pour des raisons évidentes d’étude de l’efficacité du produit, ne sont inclus dans cette etude que des animaux que ne nécesssitent pas d’autres traitement. Il s’agit don cd’une catégorie de chiens atopiques peu atteints. Comme souvent pour les traitemets topiques visant la restauration de la barrière cutanée, l’effet sur le prurit est nul.